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Aug 2015
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Dr. Andy Becker

Dr. Andy Becker

Andy Becker: stem cell pioneer and ‘amazing’ researcher

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Dr. Andy Becker, one of the true pioneers of stem cell science, has died in Toronto at age 80.

Dr. Becker was the lead author of the 1963 paper, published in Nature, that definitively demonstrated the existence of stem cells. Using chromosomal markers, he retraced their steps after they had generated the three types of precursor cells needed to make blood.

“It was a key contribution to our early experimental investigations of stem cells,”Dr. Jim Till, who was Dr. Becker’s PhD  advisor at the time, wrote via email. “His combination of talent and persistence was what was needed to complete this challenging and innovative research. I’m still amazed at what he accomplished. I doubt if anyone else, at that time, could have succeeded in the way that Andy did.”

Dr. Becker worked closely with Drs. Ernest McCulloch and Till who, in 1961, had successfully shown that single cells drawn from bone marrow could produce colony-forming units containing the precursor cells required to make white blood cells, red blood cells and platelets. That paper laid the foundation for stem cell science.

A third Till & McCulloch paper — also published in 1963 but with Dr. Lou Siminovitch as lead author –proved that stem cells not only differentiate into new cells but also have the capacity to self-renew in order to keep the process going throughout our lifetimes. Combined, the three papers essentially defined stem cells and set the stage for regenerative medicine.

Dr. Becker’s paper proved just how tenacious a researcher he  could be. The chromosomal marker method was nothing if not painstakingly frustrating, given the rudimentary technology available at the time. In the University of Toronto Press book Dreams & Due Diligence, Dr. Becker’s wife, Prof. Clelia Ganoza, explains that he had a “killer instinct” for research, which meant that “the goal is the important issue and the obstacles to overcome are just needed lessons towards this end.”

As the Toronto Star obituary explains, Dr. Becker, who was also a medical doctor, not only did seminal work with stem cells but contributed greatly to the development of recombinant DNA technology.

Here at the Canadian Stem Cell Foundation, our hearts go out to Dr. Becker’s family, especially Prof. Ganoza, his wife of 47 years.

 

2 thoughts on “Andy Becker: stem cell pioneer and ‘amazing’ researcher”

  1. Marc Perry says:

    I had just been thinking about him so much this week after seeing one of your “viral” videos on Facebook (well, viral among all the Canadian scientists that I know). I even tweeted about it, and him. When I was a brand new graduate student at U. of T. Becker and Gold were _THE_ bacteriophage lambda packaging gurus. If you wanted to clone eukaryotic genes in phage or cosmid vectors then you had to use their packaging extracts. As a brand new faculty member my lab was right next to Andy’s and for six years he was an amazing colleague and sounding board. Upon his retirement in 2000 our chair asked me to take over his lectures in the department’s flagship course for 3rd year students. I relied heavily on his lecture notes to help me plan my own. I last saw him about 10 years ago at a retirement dinner. I remember the department had a casual event when Andy retired and Jerry Hurwitz came up from Albert Einstein in the Bronx to talk about Andy’s fellowship training. I am surprised I didn’t hear of his passing through the grapevine, but I guess I am not in that loop anymore. A very sad day for Canadian science.

  2. Alexandra Becker Sielaff says:

    Marc,

    Thank you for the wonderful testmony about my father. It has been two months ago today that we lost dad. He truly was remarkable and I deeply appreciate your reflection. I am sure you did a great job lecturing. All My Best, Sandra Becker Sielaff

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