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Sep 2013
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Will enhanced stem cells mend broken hearts?

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The unveiling of a clinical trial to test the use of genetically enhanced stem cells to rebuild badly damaged hearts captured major media attention in early September.

CBC News, the Sun and Postmedia newspapers all called the trial “groundbreaking” and gave it prominent play. CTV  called it a “world-first clinical trial.” The Globe and Mail  coverage was somewhat more restrained but went into fine detail to explain how the patient’s own blood stem cells are enhanced with a gene called endothelial nitric oxide synthase (eNOS) that is then infused into the heart at the site of the damage.

It didn’t hurt that the Ottawa Hospital Research Institute, where Principal Investigator Dr. Duncan Stewart is CEO and Scientific Director, was able to put a gentle human face on complicated science by presenting Patient No. 1. Sixty-eight-year-old Harriet Garrow of Cornwall, Ontario suffered a major, heart-stopping myocardial infarction in July.  Holding hands with her husband Peter Garrow, she was amiable, articulate and authentic.  Reporting the news Sept. 10, the Aboriginal Peoples Television Network  highlighted her heritage, headlining its story “Mohawk woman in centre of ground breaking medical treatment.”

This is a double-blind study – meaning neither the investigators nor the 100 participants in Ottawa, Montreal and Toronto will know who received the souped-up stem cells or the comparative controls of ordinary stem cells or placebos until after the results are in. That doesn’t matter to Mrs. Garrow, who, at the very least, is getting the best of current cardiac care. “I am thrilled to play a part in this research that could help people like me in the future and, who knows, perhaps even my children and grandchildren,” she said in the OHRI’s media release.

A decade of work

Investigators will start analyzing the results after Patient No. 100 has been enrolled and treated – more than two years from now. By that time, Dr. Stewart will have put 10 years into the project he originally started at St. Michael’s Hospital in Toronto.

But things could happen quickly after that.

“Most major medical centres in Canada and the United States have the capacity to do this kind of cell manufacturing, “ says Dr. Stewart. “So, if we allow ourselves to dream a bit, that this really is a very positive trial with major improvements, I think it could be adopted quite quickly.”

The implications – in terms of thousands of lives that could be saved and millions of dollars in health care costs avoided – are immense. About 70,000 Canadians have heart attacks every year. Dr. Stewart estimates that about one-third of those, around 23,000, suffer damage severe enough to require this level of intervention.

“This segment of the infarct population is one that’s going to cost an awful lot of money because before they die they are going to develop heart failure. They’re going to be having multiple prolonged hospital admissions and require implantation of defibrillators and are going to have all kinds of other treatments that cost the system a lot of money.”

Other trials using ordinary stem cells have shown some positive effect on repairing heart tissue, but nothing that would spark widespread change in how heart attack patients are treated. The difference here is these stem cells have rejuvenated with eNOS to do a more effective repair job.

“It’s always been our view that getting the most robust therapy requires some manipulation of the cells, particularly when you’re using the patient’s own cells,” says Dr. Stewart. “The cells are the same age as the patient, which is usually 60 or 70 years old, and they have been exposed to the same factors that produced heart disease in the first place. We know they don’t work well. But if we can recover the activity of these cells we’re going to get more benefit.”

It all depends, of course, on The Big If: If it works.

Given the rigorous controls and criteria included in the clinical trial,  the answer should be obvious within three years.

2 thoughts on “Will enhanced stem cells mend broken hearts?”

  1. Lois Theall says:

    I look forward to hearing the results of the study. I have chronic heart failure and am undergoing stem cell treatment.

    1. Mark Ward says:

      Dear Lois,
      I had a cardiac arrest two years ago due to sarcoidosis that has disrupted the electrical system that makes the heart beat. I am curious to know if your treatment with stem cell technologies has empirically made you feel better and would you consider it has improved your quality of life?
      Regards
      Mark

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